domingo, noviembre 15, 2009

Muy buen sitio web sobre Genética y Trastorno Bipolar

Hoy estaba buscando información sobre la genética y el trastorno bipolar, y me encontré con un sitioweb muy bueno:

Dolan DNA Learning Center

En el buscador del sitio pongan "bipolar disorder" y les aparecerán casi 400 recursos interactivos, especialmente videos donde los expertos explican la relación entre herencia y trastorno bipolar. Hay varias intervenciones de la Dra. Kay Jamison. También son muy interesantes las explicaciones de la Dra. Ellen Leibenluft.

Dicen, por ejemplo, cuáles son los genes candidatos a explicar el TBP.



"We know from family and twin studies that bipolar is a highly genetic disorder. A study of 11,288 same-sex twin pairs in Denmark by Bertelsen and colleagues (1977) found that approximately 58% of monozygotic (identical) twins were concordant for bipolar disorder, as compared with 17% of dizygotic (fraternal) twins. While many genes and loci have subsequently been found to associate with bipolar disorder, none have been unambiguously identified as causal. One explanation for the difficulty in finding genes for bipolar is that it is a highly complex disorder. Genes with the strongest association are also candidate genes for schizophrenia (in particular), as well as major depression. This is not surprising given that the disorders share some common symptoms. For example, psychosis is a feature of both bipolar and schizophrenia (although the delusions and hallucination in schizophrenia seem to be related to self-awareness as opposed to mood-incongruence). Candidate genes for bipolar disorder include G72/DAOA, DISC1, NRG1, TPH2, BDNF, 5-HTT, and DAT1."

Esto me recuerda la investigación que se realiza en Costa Rica, en la UCR.

1 comentario:

navegante bipolar dijo...

Te agradezco esta información, me parece muy útil. Te felicito por dar a conocer "el trastorno" de esta manera tan amena. Un saludo ;)